Nutritional D–dependence comes from the shortcoming to transform vitamin D so you’re able to the productive form otherwise reduced responsiveness off end-areas so you’re able to enough quantities of energetic nutritional.
Kind of I vitamin D–situated rickets (pseudovitamin D–lack rickets) is actually a keen autosomal recessive problems connected with a beneficial mutation in the gene encoding the brand new step 1-alpha-hydroxylase enzyme.
During the sort of II vitamin D–built rickets, address areas dont respond to calcitriol . Vitamin D lack, hypocalcemia, and serious hypophosphatemia are present. Lees verder