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BP for the sex chromosome plus displayed quite higher maintenance ratings

We received genome-broad preservation scores, GERP (according to thirty five mammals (Cooper ainsi que al. 2005)) and PhyloP (according to 46 vertebrates (Pollard mais aussi al. 2010)) (Methods), and you may analyzed the level of evolutionary preservation in the abovementioned 19 sets of genomic metropolitan areas. A confident score indicates the condition is evolutionarily spared whereas a bad rating suggests that the position try probably developing neutrally (Figure 4e, Desk S7). Each other maintenance score was discovered to be equivalent for every updates analyzed. Many splice internet in addition to their exonic flanking nations shown an natural confident shipments of maintenance ratings, while their intronic flanking websites presented a lower life expectancy number of maintenance. Intronic positions was indeed primarily to no while exonic ranks had been mainly confident. This new BP part presented a more impressive ratio out of self-confident results (evolutionarily saved) than simply bad ratings (changing neutrally), that have a few highs out-of higher PhyloP ratings getting BP and you may BP-dos. Lees verder →