This step try mediated of the transmembrane diffusion regarding carbon dioxide you to is formed by the bicarbonate filtrated on glomerulus and an excellent proton luminally secreted away from proximal tubular epithelial cells. One transporter predominantly guilty of proton secretion throughout the lumen from the latest PT is the sodium/proton exchanger step three (NHE3) (4, 14, 172). NHE3 features the hyperlink between sodium and calcium reabsorption once again, while the genetic ablation away from NHE3 in the rats guides not only to dysfunctional proximal tubular water and you may bicarbonate reabsorption (172) and also so you can hypercalciuria and you may osteopenia (147). Lees verder →